Blar i Bergen Open Research Archive på forfatter "Schöffski, Patrick"
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Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy
Gjertsen, Bjorn T; Schöffski, Patrick (Peer reviewed; Journal article, 2015)Owing to their integral involvement in cell cycle regulation, the Polo-like kinase (Plk) family, particularly Plk1, has emerged as an attractive therapeutic target in oncology. In recent years, several Plk1 inhibitors have ... -
Metabolomic and transcriptomic response to imatinib treatment of gastrointestinal stromal tumour in xenograft-bearing mice
Macioszek, Szymon; Dudzik, Danuta; Bartoszewski, Rafał; Stokowy, Tomasz; Lambrechts, Diether; Boeckx, Bram; Wozniak, Agnieszka; Schöffski, Patrick; Markuszewski, Michał J. (Journal article; Peer reviewed, 2023)Background Although imatinib is a well-established first-line drug for treating a vast majority of gastrointestinal stromal tumours (GIST), GISTs acquire secondary resistance during therapy. Multi-omics approaches provide ...